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Home / Heart Health / Diet & Nutrition / Ultra-Processed Food May One Day Surpass Tobacco as Leading Cause of Early Death with Amy Goss, PhD
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Ultra-Processed Food May One Day Surpass Tobacco as Leading Cause of Early Death with Amy Goss, PhD

September 30, 2025 by Alain Bouchard, MD 1 Comment

This article was created with Amy Goss, PhD, Associate Professor of Nutrition Sciences at University of Alabama at Birmingham and Registered Dietitian.

Recent discussions have highlighted the significant health risks associated with ultra-processed foods (UPFs), suggesting that their consumption could one day surpass tobacco as a leading cause of early death.

Defining Ultra-Processed Foods

Professor Carlos Monteiro from Brazil coined the term “ultra-processed food” (UPF) to distinguish between natural or minimally processed foods and those that undergo extensive industrial processing. UPFs are typically formulated with additives such as preservatives, emulsifiers, artificial flavors, and color enhancers. Many of these foods, including packaged snacks, sodas, instant noodles, and processed meats, are designed for convenience and long shelf life but may offer little to no nutritional benefit.

How Ultra-Processed Foods Cause Weight Gain

Dr. Kevin Hall, a researcher at the National Institutes of Health, conducted a pivotal study demonstrating the role of UPFs in weight gain. In his experiment, participants were given either a diet consisting of ultra-processed foods or minimally processed foods. Both diets were matched for calories, sugar, fiber, and macronutrients, yet participants on the UPF diet consumed approximately 500 more calories per day than those on the minimally processed diet. Over two weeks, those eating UPFs gained an average of two pounds, while those on the unprocessed diet lost weight. The study highlighted that UPFs drive overconsumption, leading to weight gain.

How Ultra-Processed Foods Promote Overeating

UPFs are engineered to be hyper-palatable and easy to eat in large quantities. These foods are soft, calorie-dense, and packed with additives that enhance taste and texture. Emulsifiers and stabilizers enhance these foods and give them a longer shelf-life compared to their unprocessed counterparts. Additionally, emulsifiers have been shown to alter the gut microbiome in animal trials, disrupting its balance and potentially promoting inflammation and metabolic dysfunction. The almost addictive nature of UPFs, due in part to their engineered palatability, further drives overconsumption.

The Health Consequences Extend Beyond Weight Gain

While obesity is a well-known consequence of UPF consumption, the dangers extend far beyond excess weight. A meta-analysis has shown that individuals consuming diets high in UPFs had 17% more cardiovascular events and a 23% increased risk of coronary artery disease compared to those who consumed lower amounts of UPFs. Additionally, UPFs have been observationally linked to hypertension, fatty liver disease, inflammatory bowel disease, irritable bowel syndrome, anxiety, depression, and even dementia. Regular consumption is associated with an increased risk of premature death, making UPFs a public health concern comparable to tobacco.

Addressing the UPF Crisis: What Can Be Done?

Raising awareness and educating the public about the risks of UPFs is essential in combating their detrimental effects. Robert Kennedy, Jr., Secretary of the U.S. Department of Health and Human Services (HHS), has proposed several initiatives to tackle this growing crisis:

  1. Transparency and Conflict of Interest Prevention: Ensuring that federally funded research is free from corporate influence and conflicts of interest.
  2. Investigating the Root Causes of American Illness: Conducting research to determine why chronic diseases are skyrocketing in the U.S. and how diet contributes.
  3. Supporting Farmers for Better Food Availability: Working with agricultural sectors to promote the production and distribution of minimally processed, nutritious foods.
  4. Health Coverage for Lifestyle Changes: Implementing flexible health insurance policies that support dietary and lifestyle interventions to prevent chronic disease.

Conclusion

Ultra-processed foods may one day rival or even surpass tobacco as a leading driver of premature death and chronic disease. From their role in weight gain to their profound effects on metabolic health and overall well-being, these foods are contributing to an epidemic of non-communicable diseases. Tackling the UPF crisis requires a multifaceted approach, including policy changes, consumer education, and systemic food production and healthcare shifts. By taking action now, we can work towards a healthier future for all.

Risk FactorTobaccoUltra-Processed Food
All-cause mortality☠️ 8M deaths/year globally☠️ 3-4M estimated deaths/year globally
Heart disease✅✅
Cancer✅⚠️ Connection still emerging
Diabetes✅✅
Obesity❌✅
Promotes addiction✅⚠️ May promote dependency-like eating
5/5 (3)

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Filed Under: Diet & Nutrition, Featured Articles, Heart Health

Comments

  1. John Gabriel Minjares says

    October 13, 2025 at 9:15 am

    This article is a real eye opener to start eating better and taking better care of myself.

    Reply

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Alain Bouchard, MD

Dr. Alain Bouchard is a clinical cardiologist at Cardiology Specialists of Birmingham, AL. He is a native of Quebec, Canada and trained in Internal Medicine at McGill University in Montreal. He continued as a Research Fellow at the Montreal Heart Institute. He did a clinical cardiology fellowship at the University of California in San Francisco. He joined the faculty at the University of Alabama Birmingham from 1986 to 1990. He worked at CardiologyPC and Baptist Medical Center at Princeton from 1990-2019. He is now part of the Cardiology Specialists of Birmingham at St. Vincent's Health System, Ascension.

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